If your 1099-R for your annuity shows a different amount in Box 2a than in Box 1, the Box 2a is used as the taxable amount.
Box 5 may show the amount of basis (after-tax funds) applied to this year's distribution.
Because all 1099-R are considered 'retirement distributions' you can get the RMD question. Even though RMD is not required, you can answer that 'all or part of this distribution is RMD' and enter the total distribution amount as the RMD amount.
Here's more info on 1099-R for Pensions, Annuities, Retirement.
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