The Home Office Deduction is part of the self-employment business section of TurboTax, as a separate item under Expenses.
As you work through the interview for your home office, look for the page "What was the size of this home office?" Enter your square footage (office versus total) on this page. The next page allows you to choose between the simplified method and entering actual expenses.
Note that your home office deduction may be limited by your business income.
Additional info: Where do I enter the home office deduction for my business?
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