If you are using a TurboTax Desktop program, then the switch from Home and Business to Deluxe will be fine.
As stated by xmasbaby0, the Deluxe desktop version has all the forms you will need. The main difference you might see is in the interview questions and the layout of the tabs at the top. For example, there will not be a 'Business' tab at the top, but Schedule C will be included as part of the Wages and Income section.
If you are using TurboTax Online, then downgrading to the Deluxe version will not work as long as you have a Schedule C business claiming any expenses.
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