It is possible to exclude some/all of the gain on the sale of both the house you are selling in NC, as well as the house you will be selling in the future in SC, but you need to meet the rules of what is called the "Section 121 Exclusion". If the Section 121 exclusion rules are met, you can exclude up to $250,000 of gain from the sale of your personal residence ($500,000 if married filing joint) from your income . These rules are found in IRS Publication 523, located here: IRS Publication 523 . Details about the Section 121 exclusion are below:
According to this Publication: to qualify for the Section 121 exclusion, you must meet both the ownership test and the use test. You're eligible for the exclusion if you have owned and used your home as your main home for a period aggregating at least two years out of the five years prior to its date of sale. You can meet the ownership and use tests during different 2-year periods. However, you must meet both tests during the 5-year period ending on the date of the sale. Generally, you're not eligible for the exclusion if you excluded the gain from the sale of another home during the two-year period prior to the sale of your home.
It sounds like the sale of your NC home will be first - so as long as you have owned that house for at least 2 of the last 5 years, and you have lived in it for at least 2 of the last 5 years, and you had not excluded the gain from the sale of another home within the 2 years prior to the sale date of the NC home, you can take the Section 121 exclusion.
With respect to the SC second home, you would be able to take the Section 121 exclusion on that home as well, provided you meet the rules as listed above. So, you would have to have owned it and lived in it for at least 2 of the last 5 years from the date you are selling that home - AND, you cannot sell it within two years from the date you sold the NC home. So, for your situation, you need to make sure you keep track of all those dates to make sure both homes meet the rules in order to exclude gain from the sale of each of these residences.
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