Withdrew entire 401k but suffered 50k in trading options how to offset amount with 401k

I haven't been working for a year and took out my 401k.
Withdrew 100k from it without withholding early penalty of 10% and 20% for tax purposes.

 

How can I claim the 50k in trading option losses against this? I am aware that normally 3k is only allowed yearly against ordinary income.