Yes, you can, and should, e-file your tax return even if you can't pay the taxes due in full.
To do that, you can either say you are going to pay by check, or you can apply for an installment agreement.
It's important to file your return on time even if you can't pay the taxes due. This saves you from paying the failure to file penalty. You will still be charged a penalty for not paying on time, and interest on the unpaid balance.
If you say you will pay by check, a payment voucher will be printed with your return. You can mail a late payment, or a smaller payment.
If it'll take you at least six months to pay your balance due, an installment agreement is your best bet. This is a payment option in TurboTax as well.
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