Form 2210 Underpayment Penalty

When I calculate my taxes I'm told that there is no underpayment penalty yet form 2210 shows up and says that I do.  I had a home sale late in the year so estimated taxes to account for the home sale could not be anticipated, i.e., estimated.  I can check box A in part II on 2210 to waive the entire penalty but then I'm told that I cannot eFile.  Should I simply not file the 2210?