You appear to be referring to whether or not you must enter the sale of your home on a tax return. If you qualify for the up to $250,000 ($500,000 if MFJ) of capital gains exclusion, you may not need to include the sale on your tax return. However, there are situations where it must be included even if the capital gains are less than the exclusion.
You must enter the sale on your tax return using Premier if you rented out the home at some point, you claimed a home office deduction, or you received a Form 1099-S for the sale of the home.
