Yes, the main difference is that with Live Assist, you get a full review by a tax expert as well as expert assistance as you prepare your tax return. The price is for a single federal return and there are extra charges for state returns.
With TurboTax Desktop, you can submit up to five federal e-files for one license. States are extra. You can get help over the phone using TurboTax Support, but they won't review every aspect of your return.
You can get all the details of both options, here.
With all TurboTax products, you can get help through the Community forum.
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