Just to elaborate what has already been mentioned, you may claim a home office expense if you used it, owned a business, and then used a portion of your home to conduct your business. You cannot use it to conduct work at home if you are an employee according to IRS guidelines.
If this was used as a rental at any time, there may be ordinary income that may be taxed in addition to the capital gains tax that might be owed due to depreciation recapture. If this is the case with you, please respond back @DaveF1006 and I will explain to you how to report the sale.
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