A lot of people are having trouble efiling with a Schedule C right now. I personally do not know the reason, but several folks have phoned Customer Support, and TurboTax is aware of the problem. See if anything changes after their routine weekly software update which normally occurs overnight on early Thursday mornings. I don't know if something is wrong with the Sched C itself, or if it's related to some underlying form that flows to the Schedule C. TurboTax normally puts out new desktop updates overnight on early Thursday mornings. The program usually has some bugs each year in early filing season.
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