2018 tax extension has been filed. How to handle 2019 Payment 1 estimated taxes?

I am required to pay 2019 estimated taxes. I have a refund coming for 2018, which has not been issued yet because of extension. What am I supposed to do for the April 15th payment for 2019 estimated taxes?  Can this be considered as I applied my refund to that payment?  Or I need to pay IRS now because taxes have not been filed yet so refund is still considered "hypothetical"?