Make sure you don't have any external drives connected to your computer (even if you're installing to C drive).
Have you installing on another computer? One year I had to use my husband's computer to do our taxes, even though TurboTax had installed fine the year previously (and the year after) on my laptop.
Here's info on Troubleshooting Installation that may help you, if you haven't tried these steps yet.
Other users have suggested switching between accounts on your computer (if you have them), and using one to install and one to run the program.
You may need to Contact Support and let them get into your computer if you can't resolve your installation issue.
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