You won't be able to deduct mortgage interest (if you did). You won't be able to deduct property taxes (if you did).
If you got a 1099-S at the closing, you have to report the sale even if no capital gains tax will be owed.
If you ever used the home in business (such as a home office or rental) then some of your gain is taxable due to depreciation recapture, even if your gain is less than the $250,000 personal exclusion.
No other impact I can think of.
