IRS Tax Estimator Calculator

I have used the Tax Calculator from the IRS website and my withholdings are correct, however I owe $6300 more than it says I should owe. How can that be? I save 18% of my salary in 401K to reduce my taxable income. The IRS calc says I should owe $1400 but Turbo Tax says I owe $7700. How can I verify what my withholding should be if the IRS and Turbo Tax are so far apart? I have all the recent software updates.