The phrase "amount applied from 2021 return" refers to a situation where you had a refund in 2021 and you chose to apply the amount to your 2022 estimated taxes rather than getting a check or direct deposit.
2022 estimated tax payments are quarterly payments that you make when you think you will owe more tax than the amount you are having withheld.
Entries for either of these will be added as payments to your return and you will show a higher refund. Fortunately the IRS knows whether you made those payments and adjusted your refund.
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