No, it should not. Line 6 on Schedule C, Profit or Loss From Business, relates to other income earned in connection with the trade or business. A 1099-INT is entered into TurboTax in the Investment and Savings section (TurboTax online) or the Investment Income section (TurboTax CD/download).
After entering the 1099-INT into TurboTax, this interest income will appear on Schedule B, Interest and Ordinary Dividends, and it will also appear on line 2b of Form 1040.
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