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I am getting the same error when I try to e-file my amended 2021 taxes... 

 

Ran into the same signature date problem as @dmcmtax reported... Ended up using the date that I e-Filed the original 2021 taxes - and maybe as the OP says, that is the problem that caused a validation error.  In my error statement it says had problems with validation, and also TurboTax reports:

 

- E - File for this agency and filing type is no longer available.  Please file any pending returns on paper.

 

SO, to echo @dmcmtax  - is the problem the signature date?  Or is the problem that it is too late to e-File 2021 amended taxes?  Inquiring minds want to know... Am hoping there is a fix/workaround to get the taxes e-File'd... will save time, and $$s...