No, there's nothing wrong with the negative computed value you're seeing on line 1 of Form 104. Rest assured that the state program is working as intended.
This simply reflects an inconsistency in the instructions between your federal and state returns.
If you'll look at your federal Form 1040, the instruction next to line 15 is " If zero or less, enter -0-." So, even if the actual computation was negative, you'd need to enter a zero amount on line 15.
However, the DR 104 Book line 1 states that the amount should be entered as a negative:
If your federal taxable income is a negative amount, be sure to enter the amount as such on your Colorado return. If submitting a paper return, put the negative amount in parentheses, for example ($1,234).
