QCDs can only be made from IRAs. If you want to make a QCD from funds that are presently in a 401(k), you'll need to roll those funds over to an IRA and then make the QCD from the IRA. Once you reach the year that you reach age 72 you'll need to satisfy the RMD from the 401(k) before rolling any other amounts from the 401(k) over to an IRA.
