Hi Mr and Mrs B, You would not include your spouse as your dependent, so leave that line blank.
For your upcoming change there are several factor to consider, such as if your employer is paying your expenses or reimbursing you. Since you are a W-2 employee you can no longer take a deduction for nonreimbursed business expenses so there would be no affect on your withholdings.
It's always a good idea keep a close eye on your paychecks to see your federal income tax withholding and compare to your 2021 tax return.
I hope this is helpful!
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