with those kinds of figures..you really need to be working with a local-reliable professional.
......but that's why the IRS wants to get paid quarterly....it cannot depend on you paying later it if you spend or gamble it all away and plead you are broke at tax time.
With a million or more in income by the end of the year, unless you have some claimable losses to offset it, the fed tax will be ~37% on the amount above $500k for a single person so, pay say 300k-350k /million to the IRS ...and depending on which state you live in... $50k-to$80k to them (if you are in an income taxing state.)
No way anyone can advice you accurately though..you need a local pro to examine the details of yoru situation.
.....or if a pro athlete, then you really DO need to talk to your experienced teammates, and coaches, since you may be taxed in a whole lot of states. (pro athletes need special tax preparers)
____________*Answers are correct to the best of my knowledge when posted, but should not be considered to be legal or official tax advice.*