If you are a sole proprietor reporting your business income and expenses on Schedule C, then your charitable contributions will be reported on Schedule A Itemized Deductions no matter which account you use to make the donation.
An exception to this would be if you received a business benefit in return for your donation. For example, if you donated money to a charity event as a sponsor and in return your business was promoted in the event program. Then your donation could count as a business expense on Schedule C instead of a donation on Schedule A.
If possible, you would most likely get more benefit from being able to take a business expense deduction. You just need to be strategic with your donations.
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