If we're talking about a traditional IRA (vs a Roth) then the tax benefits between a self-directed IRA and a self-employed 401K are about the same. Administration costs are something to take into account. And if you're going the self-directed IRA route you need to make sure that you know what you're doing with the investments that you select.
Far from retirement they are also pretty similar. Closer to retirement the 401K has higher contribution limits so that is the better choice.
@pkiran
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