I'm traveling to Mexico to film some videos for an online program I am creating. Can I deduct the travel expenses (airfare, other transport, hotel, meals)?

[Opus 17]

Generally speaking, self-employed persons can deduct travel expenses that are "ordinary and necessary" for their specific job.  The exact rules are in publication 463; generally, you can deduct actual expense for travel and lodging and 50% of your meals.

https://www.irs.gov/pub/irs-pdf/p463.pdf

These expenses are reported on schedule C as a deduction against your income.  If your business is not active yet, and these are "startup expenses", and your business is still not active as of December 31, 2021, then startup costs are handled somewhat differently, and we can discuss that if needed.