No - Don't skip the screen, Sale of a Home. If you were issued a 1099-S for the sale of your principal residence, you are required to report the sale on your return.
According to IRS Topic 701 –
Sale of Your Home:
If you receive an informational income-reporting document such as Form 1099-S.pdf, Proceeds From Real Estate Transactions, you must report the sale of the home even if the gain from the sale is excludable.
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