Yes. There are a few different limits on the total amount of contributions you can deduct.
The amount you can deduct for charitable contributions generally is limited to 50% of your adjusted gross income. Your deduction may be further limited to 30% or 20% of your adjusted gross income, depending on the type of property you give and the type of organization you give it to.
Also, for 2016, the total of your charitable contributions
deduction and certain other itemized deductions
may be limited if your adjusted gross
income is more than:
$155,650 if married filing separately,
$259,400 if single,
$285,350 if head of household,
or
$311,300 if married filing jointly or qualifying
widow(er).
You can view more information about these limit amounts at the link below (pages 13-16)
https://www.irs.gov/pub/irs-pdf/p526.pdf