I have a second job out of town every other weekend (PRN). It requires a hotel stay, can the hotel expense be deducted on my taxes?

[daisie78]

the job is 2.5 hrs travel time from my home. 

[CathiM]

Yes, if you are an employee, you have to itemize on Schedule A and report it as an unreimbursed employee expense on form 2106, see instructions below.  This means that your Schedule A expenses need to total more than the Standard Deduction.  See below for how to do this.  

If you are self-employed (receive a 1099-MISC), include them as travel expenses under self-employed income and expenses.

https://ttlc.intuit.com/replies/3300652

https://ttlc.intuit.com/replies/4800418