Can I deduct my self employed business expenses, ex. home office, computer, etc., for each line of work one or is just one time for all lines of work?

[Critter · Accepted solution]

No matter how many Sch C's you file you cannot take the same expenses more than once  on more than one of the Sch C forms. 

Now if you only file one Sch C then I presume you mean you get a separate 1099 from each client ... so all the "lines of work" are entered on the same Sch C form and all expenses likewise.