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No, you cannot mix and match when you are married. The IRS requires that if one spouse itemizes, the other must also itemize (even if their deductions are $0).
Your wife is correct about the marketplace insurance (1095-A). To be eligible for the Premium Tax Credit, the IRS generally requires you to file a joint return. See: Eligibility for the Premium Tax Credit
If your spouse has self-employment income, her business expenses go on Schedule C. That is different from the Schedule A where you enter "itemized" deductions such as mortgage interest, medical expenses etc. You can use standard deduction and have Schedule C on the same joint tax return.
If you have self-employment income for which you will pay self-employment tax for Social Security and Medicare, you will need to use online Premium software or any version of the desktop software download so that you can prepare a Schedule C for your business expenses.
https://ttlc.intuit.com/community/self-employed/help/what-is-the-self-employment-tax/00/25922
If you live in a state with a state income tax, you might need to make estimated payments to your state.
https://turbotax.intuit.com/tax-tips/small-business-taxes/the-home-office-deduction/L1RZyYxzv
https://turbotax.intuit.com/tax-tools/calculators/self-employed/
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