Yes.

Please see this LINK for a more thorough discussion of the topic.

Thank you for the reply.  Are you sure that this applies to second residences, not rental homes?  I can only find information on rental homes, such as the link you referenced. This second property is not a rental.

You can generally only deduct the interest if it was used to buy, build, or substantially improve your home.   It can apply to a rental home, but it does not apply to the purchase of a second home that you bought with the money from the cash-out refinance.  

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