Yes, and more.  Whether you are an employee going on business trips or a business owner traveling for business, you are able to deduct the cost of your car using either the Standard Mileage Deductions, which for 2016 is $0.54 or the Exact Expense (the cost for oil changes, repair etc.) all based on the amount of time the car is used for business.  To learn more about deductions for business trips and the requirements please read Turbo Tax Tax Deductions For Business Travelers and Taking Business Tax Deductions.