What filing status should I file if I am married, but have not lived with my spouse since 2016?

I have 4 dependents from a previous relationship that I take care of in my own home. 

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How are you legally related to the "4 dependents from a previous relationship" that you take care of? Did they live with you all year?

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They are my children and yes they have been living with me all year.

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In the interview you will choose the marital status as married and then choose to NOT file a joint return and when you enter in any qualifying dependents the Head of Household filing status will be suggested.

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How did you file for 2016 and 2017?

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In the interview you will choose the marital status as married and then choose to NOT file a joint return and when you enter in any qualifying dependents the Head of Household filing status will be suggested.