Yes, if you have a W2 (see screenshot below), a valid SSN or ITIN, and Box 15 is populated with a withholding for Puerto Rico, you can file a Federal Income Tax Return on TurboTax. Unfortunately TurboTax does not offer a product to prepare your Income Tax Return for the Departamento de Hacienda de Puerto Rico. This must be prepared by other means. Please click on the link below for more information: 

http://www.hacienda.pr.gov/individuos/contribucion-sobre-ingresos