Tax Year Prior to 2020: Box 16 on my W2 doesn't equal box 1 or box 3 and 5

[KarenL2]

That is unusual unless you have income from more than one state.  You might want to contact your employer to confirm your W-2 is accurate.  If it isn't, they need to file a Corrected W-2 with the IRS, state, and provide one to you as well.