My wife didn't have SS# in 2016 and turbo tax didn't let me file without it so I filed as single but now it's giving me some trouble and I need to fix it. Can I amend it?

[DoninGA]

You will need to amend the 2016 tax return and change your filing status to Married Filing Separately if your spouse did not have SS number or an ITIN issued by the IRS in 2016.

See this TurboTax support FAQ for amending a 2016 tax return originally completed and filed using TurboTax - https://ttlc.intuit.com/questions/3061514-how-do-i-amend-a-2016-return-in-turbotax

If you are a US citizen or US resident and your spouse does not have a Social Security number or an ITIN and you are not applying for an ITIN with the tax return then you can only file your tax return as Married Filing Separately.  Where asked to enter the spouse's Social Security number enter 999-88-9999.  You can only print and mail your tax return, it cannot be e-filed.  When you print the tax return erase the Social Security number for your spouse and manually enter NRA for non-resident alien.

[Opus 17]

You could also file as married filing jointly, if you want to declare and pay income tax on your wife's world-wide income for 2016.  This may be a better choice if she had no income.

Note that if your spouse now has an SSN or ITIN, your tax return may show additional benefits such as EIC or certain other credits.  However, the IRS won't pay those benefits because your spouse did not have an ITIN or SSN by the original April 2017 deadline.