If I complete my e-file and sign, I'm always informed to print my return and mail it in. I've used the similar information the last few years. What is the reason?

[Mike9241]

we can not see your return so these are guesses. If you are seeing "Ready to mail," it means you chose the File by Mail option instead of e-File. there is no signature for an e-filed return but rather the prior year's Adjusted Gross Income  is needed to e-file.  Another reason could be that you need to attach a form that Turbotax does not support or you are trying to file when a form in your return is not final for 2022 but you should have seen that warning. 

I recommend you contact support who you can allow to review your return to find the reason

Contact Customer Service
5am-5pm Pacific Time (8-8 Eastern) Monday - Friday
https://support.turbotax.intuit.com/contact

800-446-8848

[SteamTrain]

If you always owe something...are you sure it's not just asking you to print and mail in the 1040-V voucher and a payment check?

Certainly, you should download the PDF every year to your own computer...and not depend on immediate/easy access to your tax file in the future.